SUN-023 INVOLVEMENT OF CHRONIC EPIPHARYNGITIS AS A TRIGGER OF GLOMERULAR VASCULITIS IN IGA NEPHROPATHY
نویسندگان
چکیده
منابع مشابه
Role of Glomerular Proteoglycans in IgA Nephropathy
Mesangial matrix expansion is a prominent feature of the most common form of glomerulonephritis, IgA nephropathy (IgAN). To find molecular markers and improve the understanding of the disease, the gene and protein expression of proteoglycans were investigated in biopsies from IgAN patients and correlated to clinical and morphological data. We collected and microdissected renal biopsies from IgA...
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Compelling evidence points to a role for IgA receptors in the pathogenesis of IgA nephropathy. The soluble form of the type I IgA receptor (FcalphaRI or CD89) forms complexes with IgA that can be found in patients' serum and that initiate the disease in CD89 transgenic mice. A nonclassic IgA receptor, identified as the transferrin receptor (TfR), is highly expressed in patients' mesangium and c...
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IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis in the developed world and it is an important cause of end stage kidney failure. Epidemiologic studies have shown that IgAN is nearly universally distributed around the world but the frequency with which it is diagnosed varies, mostly according to local policies regarding the indications for renal biopsy. Prevalence ap...
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IgA nephropathy (IgAN) is characterized by mesangial deposition of polymeric IgA1 (pIgA1) and complement. Complement activation via mannose-binding lectin and the lectin pathway is associated with disease progression. Furthermore, recent studies have indicated a possible role for secretory IgA. IgAN is associated with abnormalities in circulating IgA, including aberrant O-linked glycosylation. ...
متن کاملAberrantly glycosylated IgA1 in glomerular immune deposits of IgA nephropathy.
In IgA nephropathy, abnormal O-glycosylation of IgA1 molecules contributes to mesangial IgA1 deposition and the development of glomerular injury; however, direct in situ demonstration of aberrantly O-glycosylated IgA1 within glomerular immune deposits has not been reported. This study investigated the presence of abnormally glycosylated IgA1 in situ and its spatial relationship with complement ...
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ژورنال
عنوان ژورنال: Kidney International Reports
سال: 2019
ISSN: 2468-0249
DOI: 10.1016/j.ekir.2019.05.418